Derrick Henry rushed for 178 yards and three touchdowns to lead the Tennessee Titans to a 45-26 win over the Indianapolis Colts Sunday. Ryan Tannehill completed 13 of 22 passes for 221 yards and a touchdown, and also ran for a score in the win. Tennessee moves into first place in the AFC South with an 8-and-3 record. The Colts fall to 7-and-4. The Titans return to action next Sunday against the Cleveland Browns.