KY 181 in southern Todd County will close at the railroad crossing for several days beginning Monday of next week to allow for maintenance.
The Kentucky Transportation Cabinet says a detour will be set up along KY 848 and US 79.
The KY 181 crossing is just north of Cal-Maine Foods a couple miles north of Guthrie.
The railroad crossings on KY 848, KY 104 and KY 475 in the Trenton area will close on separate schedules for maintenance the following week.